Glutamate and GABA can be thought of as mainstay neurotransmitters. They slog away in high concentrations within the brain where one (glutamate) is the throttle and the other (GABA) acts as the brake. Glutamate has an important role in learning and memory, but too much and it can lead to agitation, impulsive behavior and even violence. GABA has the opposite effect. It increases our levels of tranquility by inhibiting too much nerve activity.
http://www.healthcentral.com/slideshow/getting-to-know-your-5-essential-brain-chemicals#slide=2